| - If you have liver disease. CELEBREX has significant drug interactions with : - Methotrexate (a medicine used to suppress the immune system). Do not take CELEBREX if you: - Lithium (a medicine used to treat a certain type of depression). - Serious allergic reactions including swelling of the face, lips, tongue, and/or throat which may cause difficulty breathing or swallowing and wheezing occur rarely but may require treatment right away. Severe skin reactions have also been reported. - Severe liver problems, including hepatitis, jaundice and liver failure, occur rarely in patients taking NSAIDs, including CELEBREX. Symptoms of liver problems include nausea, tiredness, itching, tenderness in the right upper abdomen, and flu-like symptoms. The following Information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. - Warfarin (a blood thinner). - You should continue to take CELEBREX as prescribed even when you are feeling better. CELEBREX can be taken with or without food. CAN I TAKE CELEBREX IF I AM TAKING OTHER MEDICATIONS? NO. CELEBREX cannot be expected to substitute for corticosteroids or to treat corticosteroid insufficiency. Abrupt discontinuation of this medicine may lead to exacerbation of corticosteroid-responsive illness. Patients on prolonged corticosteroid therapy should have their therapy tapered slowly if a decision is made to discontinue this medication. Tell your doctor your medical history, especially of: any liver or kidney disease, blood disorders, porphyria, asthma, any allergies. When rising quickly from a sitting or lying position, dizziness or lightheadedness may occur. Change positions slowly. Use caution engaging in activities requiring alertness (such as driving) if this drug makes you dizzy or drowsy. Limit alcohol intake while taking this medication. This drug should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. Carisoprodol is excreted into breast milk. Consult your doctor before breast-feeding. Tell your doctor of all over-the-counter and prescription medication you may take including: sedatives, tranquilizers, sleeping pills, narcotic pain relievers, medication for depression and certain antihistamines (e.g., diphenhydramine). Many cough-and-cold products contain antihistamines, which can cause drowsiness. Check labels carefully and consult your pharmacist if you have any questions. Do not start or stop any medicine without doctor or pharmacist approval. - Rifampin (an antibiotic). - In Osteoarthritis, the recommended dose for VIOXX is 25 to 50 mg a day. VIOXX delivers 24-hour relief from a once-daily dose. |