| - Severe liver problems, including hepatitis, jaundice and liver failure, occur rarely in patients taking NSAIDs, including CELEBREX. Symptoms of liver problems include nausea, tiredness, itching, tenderness in the right upper abdomen, and flu-like symptoms. Do not take CELEBREX if you: - have had an allergic reaction to celecoxib, which is the active ingredient of CELEBREX any of its inactive ingredients. - Rifampin (an antibiotic). - Serious kidney problems occur rarely, including acute kidney failure and worsening of chronic kidney failure. - Warfarin (a blood thinner). - ACE inhibitors (medicines used for high blood pressure and heart failure). - If you have liver disease. - If you have liver disease. If you are one of the many people who take low-dose aspirin for the prevention of heart attack or stroke, you can still take CELEBREX. However, taking CELEBREX and aspirin together can increase your risk for developing stomach ulcers compared to taking CELEBREX alone. CELEBREX is not a substitute for aspirin for heart attack or stroke prevention. Celebrex is a non-steroidal anti-inflammatory drug (NSAID) that represents a huge breakthrough in the treatment of pain, inflammation, and stiffness of arthritis. - In analgesia and dysmenorrhea, the recommended dose for VIOXX is also 25 to 50 mg once a day. VIOXX provides relief through the day and through the night. SIDE EFFECTS that may occur while taking Vioxx include weakness or nausea. If they continue or are bothersome, check with your doctor. CHECK WITH YOUR DOCTOR AS SOON AS POSSIBLE if you experience itching or skin rash, swelling of the feet or ankles, unexpected weight gain, vomiting material that looks like coffee grounds, or blood in stool or vomit. CONTACT YOUR DOCTOR IMMEDIATELY if you experience swelling of hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; hoarseness; flu-like symptoms; sluggishness; yellowing of the skin or eyes; stomach pain; dark urine or pale stools; or unusual fatigue. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist. Vioxx is a nonsteroidal anti-inflammatory drug (NSAID) known as a COX-2 inhibitor used to relieve the symptoms of osteoarthritis and to treat pain and menstrual discomfort. - Warfarin (a blood thinner). |