| CELEBREX has significant drug interactions with : - In Osteoarthritis, the recommended dose for CELEBREX is 100 - 200 mg a day. CELEBREX delivers 24-hour relief from a once-daily dose of 200 mg. - Lithium (a medicine used to treat a certain type of depression). - Rifampin (an antibiotic). - If you have kidney disease. - In Osteoarthritis, the recommended dose for VIOXX is 25 to 50 mg a day. VIOXX delivers 24-hour relief from a once-daily dose. - Serious stomach problems, such as stomach and intestinal bleeding, can occur with or without warning symptoms. These problems, if severe, could lead to hospitalization or death. Although this happens rarely, you should watch for signs that you may have this serious side effect. - ACE inhibitors (medicines used for high blood pressure and heart failure). DO NOT TAKE VIOXX IF YOU HAVE HAD A SEVERE ALLERGIC REACTION to aspirin or any medicine containing aspirin or to a nonsteroidal anti-inflammatory drug (such as Feldene, Motrin, Naprosyn, Clinoril). A severe reaction includes a severe rash, hives, breathing difficulties, or dizziness. If you have a question about whether you are allergic to Vioxx or if a certain medicine is a nonsteroidal anti-inflammatory drug, contact your doctor or pharmacist. IF YOU EXPERIENCE difficulty breathing; tightness of chest; swelling of eyelids, face, or lips; or if you develop a rash or hives, tell your doctor immediately. Do not take any more doses of Vioxx unless your doctor tells you to do so. DO NOT EXCEED THE RECOMMENDED DOSE or take Vioxx for longer than prescribed without checking with your doctor. KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS while you are using Vioxx. ALCOHOL WARNING: If you consume 3 or more alcoholic drinks every day, ask your doctor whether you should take Vioxx or other pain relievers/fever reducers. This medicine may cause stomach bleeding. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. This includes any medicines that contain ibuprofen, naproxen, or ketoprofen. FOR WOMEN: IF YOU PLAN ON BECOMING PREGNANT, discuss with your doctor the benefits and risks of using Vioxx during pregnancy. IT IS UNKNOWN IF VIOXX IS EXCRETED in breast milk. DO NOT BREAST-FEED while taking Vioxx. - Methotrexate (a medicine used to suppress the immune system). - Warfarin (a blood thinner). - Warfarin (a blood thinner). - ACE inhibitors (medicines used for high blood pressure and heart failure). |